1609183-52-9Relevant academic research and scientific papers
Rh-Catalyzed General Method for Directed C-H Functionalization via Decarbonylation of in-Situ-Generated Acid Fluorides from Carboxylic Acids
He, Bangyue,Liu, Xiaojie,Li, Hongyi,Zhang, Xiaofeng,Ren, Yuxi,Su, Weiping
, p. 4191 - 4196 (2021)
A Rh-catalyzed decarbonylative C-H coupling of in-situ-generated acid fluorides with amide substrates bearing ortho-Csp2-H bonds has been developed. This method enables alkyl, aryl, and alkenyl carboxylic acids to undergo decarbonylative coupling with C-H bonds of (hetero)aromatic or alkenyl amides in generally good yields via the in situ conversion of carboxylic acids into acid fluorides and also allows for the functionalization of a series of structurally complex carboxyl-containing natural products and pharmaceuticals as well as pharmaceutical amide derivatives.
Nickel-catalyzed C-H alkylations: Direct secondary alkylations and trifluoroethylations of arenes
Song, Weifeng,Lackner, Sebastian,Ackermann, Lutz
supporting information, p. 2477 - 2480 (2014/03/21)
A versatile nickel catalyst allowed for C-H alkylations of unactivated arenes with challenging secondary alkyl bromides and chlorides. The high catalytic efficacy also set the stage for direct secondary alkylations of indoles as well as C-H trifluoroethylations with ample substrate scope. In an absence of activation: A robust nickel(II) catalyst enabled secondary alkylations of unactivated aryl C-H bonds with secondary alkyl bromides and chlorides with ample substrate scope. Based on this system the first C-H trifluoroethylations of arenes with unactivated C-H bonds could be carried out (see scheme; Q=8-quinolinyl). Copyright
