1609184-89-5Relevant academic research and scientific papers
Novel synthesis of carbohydrate fused α-amino γ-lactams and glycopeptides by NIS mediated ring opening of donor-acceptor substituted cyclopropanes
Kishore, Gade,Gautam, Vibha,Chandrasekaran, Srinivasan
, p. 1 - 8 (2014/04/17)
α-Amino γ-lactams have been synthesized from carbohydrate derived cyclopropanecarboxylates using N-iodosuccinimide (NIS) and NaN 3. Cyclopropane ring opening with NIS and NaN3 in different solvents has been studied. Reductive cyclization of the intermediate di-azides leads to the carbohydrate fused α-amino γ-lactam and γ-lactams. Additionally, the methodology has been successfully extended to the synthesis of a glycopeptide.
