1609199-90-7Relevant articles and documents
Discovery of small molecular (d)-leucinamides as potent, Notch-sparing γ-secretase modulators
Liao, Yung-Feng,Tang, Yu-Cheng,Chang, Ming-Yun,Wang, Bo-Jeng,Hu, Ming-Kuan
, p. 143 - 151 (2014/05/06)
Structural optimization of the prior lead 3 led to the small molecular (d)-leucinamides with potent modulating activity and Notch-sparing selectivity on the proteolytic processing of amyloid-β precursor proteins. The N-(R)-epoxypropyl analog 10c exhibited