1609205-85-7Relevant academic research and scientific papers
Highly stereoselective ruthenium(II)-catalyzed direct C2- syn -alkenylation of indoles with alkynes
Zhang, Wei,Wei, Jun,Fu, Shaomin,Lin, Dongen,Jiang, Huanfeng,Zeng, Wei
supporting information, p. 1349 - 1352 (2015/03/30)
A carboamide-directed ruthenium-catalyzed C2-hydroindolation of alkynes has been described. This transformation provides a rapid access to free (N-H) C2-syn-alkenylated indole derivatives with the assistance of copper(II) salts, in which the directing group is removed via a one-pot process.
Rh-catalyzed oxidative C2-alkenylation of indoles with alkynes: Unexpected cleavage of directing group
Sharma, Satyasheel,Han, Sangil,Shin, Youngmi,Mishra, Neeraj Kumar,Oh, Hyunji,Park, Jihye,Kwak, Jong Hwan,Shin, Beom Soo,Jung, Young Hoon,Kim, In Su
, p. 3104 - 3107 (2014/05/20)
A rhodium-catalyzed oxidative C2-alkenylation of indoles containing a N-(p-tolyl)carboxamide group with substituted alkynes via C-C bond formation and subsequent C-N bond cleavage has been described. This protocol represents direct access to C-2-alkenylated free (NH)-indoles, which are important building blocks in the synthesis of natural and pharmacological compounds.
