1571899-52-9

Upstream product

• 17422-32-1 5-chloro-1H-indole 
• 622-58-2 p-Tolylisocyanate 

Downstream Products

• 1571899-70-1 (E)-benzyl 3-(5-chloro-1H-indol-2-yl)acrylate 
• 1571899-71-2 (E)-phenyl 3-(5-chloro-1H-indol-2-yl)acrylate 
• 1571899-73-4 (E)-5-chloro-2-(2-(phenylsulfonyl)vinyl)-1H-indole 
• 1571899-80-3 (E)-5-chloro-2-(pentafluorostyryl)-1H-indole 
• 1609205-87-9 (E)-diethyl 4,4'-(1-(5-chloro-1H-indol-2-yl)ethene-1,2-diyl)dibenzoate 
• 1609205-86-8 (E)-2-(1,2-bis(4-fluorophenyl)vinyl)-5-chloro-1H-indole 
• 1609205-84-6 (E)-5-chloro-2-(1,2-diphenylvinyl)-1H-indole 
• 1609205-85-7 (Z)-5-chloro-2-(1,2-diphenylvinyl)-1H-indole 

Relevant academic research and scientific papers

Copper(I)-Catalyzed N-Carboxamidation of Indoles with Isocyanates: Facile and General Method for the Synthesis of Indole-1-carboxamides

A facile and general method for the synthesis of indole-1-carboxamides was developed via copper(I)-catalyzed N-carboxamidation of indoles with isocyanates under mild reaction conditions. This process is scalable and tolerates a wide spectrum of indoles and isocyanates to deliver corresponding products in good to excellent yields, providing a viable synthetic approach to indole-1-carboxamides, which can be used for the treatment of inflammatory diseases and diabetes.

Rh-catalyzed oxidative C-C bond formation and C-N bond cleavage: Direct access to C2-olefinated free (NH)-indoles and pyrroles

The rhodium-catalyzed oxidative C2-olefination of indoles and pyrroles containing N-arylcarboxamide directing groups with a range of alkenes and subsequent cleavage of directing groups is described. This method provides direct and efficient access to C2-functionalized free (NH)-heterocycles.

Rh-catalyzed oxidative C2-alkenylation of indoles with alkynes: Unexpected cleavage of directing group

A rhodium-catalyzed oxidative C2-alkenylation of indoles containing a N-(p-tolyl)carboxamide group with substituted alkynes via C-C bond formation and subsequent C-N bond cleavage has been described. This protocol represents direct access to C-2-alkenylated free (NH)-indoles, which are important building blocks in the synthesis of natural and pharmacological compounds.