1609255-02-8Relevant academic research and scientific papers
Novel and efficient synthesis of 4-indazolyl-1,3,4-trisubstituted pyrazole derivatives
Hote, Baliram S.,Lokhande, Pradeep D.
supporting information, p. 1492 - 1500 (2014/05/20)
In the present study, 1-(4,5-dihydro-3,6-dimethyl-4-(1,3-diphenyl-1H- pyrazol-4-yl)-3aH-indazol-5-yl)methanone derivatives (9-12) and isoxazoleyl (13-16) have been synthesized by the condensation of 1,3-diphenyl-1H-pyrazole-4- carbaldehyde (1-4) with acetyl acetone via Knoevenagel/Michael/aldol reactions in a sequential manner to yield intermediate cyclohexanone (5-8). The intermediates (5-8) treated with NH2NH2·H 2O/NH2OH·HCl afforded 4-indazolyl-1,3,4- trisubstituted pyrazole and isoxazoleyl derivatives. All of these compounds are reported for the first time, and the structures of these compounds were confirmed by means of infrared, 1H NMR, 13C NMR, and mass spectroscopy.
