160929-10-2Relevant academic research and scientific papers
Zirconium-mediated intramolecular coupling of terminal alkynes and their subsequent carbonylation: Novel synthesis of seven- and eight-membered heterocycles
Barluenga, Jose,Sanz, Roberto,Fananas, Francisco J.
, p. 1324 - 1336 (2007/10/03)
The development of a new method for the intramolecular coupling of terminal alkynes and for the synthesis of seven- and eight-membered benzoheterocyeles is reported. The key steps involve the generation of zirconocene-alkyne complexes from 2-bromoalkenes and the subsequent intramolecular carbometalation of olefins or acetylides. The 8-unsubstituted zirconabicyclopentenes were carbonylated to afford unexpected products and allow access to polyfunctionalized molecules from simple starting materials.
