1609338-19-3Relevant academic research and scientific papers
Design, synthesis and biological evaluation of some novel substituted quinazolines as antitumor agents
Alanazi, Amer M.,Abdel-Aziz, Alaa A.-M.,Al-Suwaidan, Ibrahim A.,Abdel-Hamide, Sami G.,Shawer, Taghreed Z.,El-Azab, Adel S.
, p. 446 - 454 (2014/05/06)
A novel series of 6-chloro-2-p-tolylquinazolinone and substituted-(4- methylbenzamido)benzamide (1-20) were designed, synthesized and evaluated for their in-vitro antitumor activity. Compounds 3, 14 and 16 possessed remarkable broad-spectrum antitumor activity. Compound 16 was found to be a particularly active growth inhibitor of the renal cancer (GI50 = 4.07 μM), CNS cancer (GI50 = 7.41 μM), ovarian cancer (GI50 = 7.41 μM) and non-small cell lung cancer (GI50 = 7.94 μM). Compound 16 ranks as nearly 1.5-fold more potent (mean GI50 = 15.8 μM) compared to 5-FU (mean GI50 = 22.6 μM).
