1609356-87-7Relevant academic research and scientific papers
Asymmetric Conjugate Addition of Ethylene Sulfonyl Fluorides to 3-Amido-2-oxindoles: Synthesis of Chiral Spirocyclic Oxindole Sultams
Chen, Jie,Huang, Bao-Qin,Wang, Zeng-Qing,Zhang, Xue-Jing,Yan, Ming
, p. 9742 - 9746 (2019)
An enantioselective conjugate addition of ethylene sulfonyl fluorides to 3-amido-2-oxindoles has been developed. Quinine-derived squaramides were identified as efficient catalysts. A series of spirocyclic oxindole sultams were prepared with excellent yields and enantioselectivities. A reaction mechanism via bifunctional activation was proposed.
Tandem michael addition-ring transformation reactions of 3-hydroxyoxindoles/3-aminooxindoles with olefinic azlactones: Direct access to structurally diverse spirocyclic oxindoles
Cui, Bao-Dong,Zuo, Jian,Zhao, Jian-Qiang,Zhou, Ming-Qiang,Wu, Zhi-Jun,Zhang, Xiao-Mei,Yuan, Wei-Cheng
, p. 5305 - 5314 (2014/06/23)
An efficient method for the direct construction of two classes of spirocyclic oxindoles by the reactions of 3-hydroxyoxindoles/3-aminooxindoles and (Z)-olefinic azlactones through a tandem Michael addition-ring transformation process has been developed. With DBU as the catalyst, a range of spiro-butyrolactoneoxindoles and spiro-butyrolactamoxindoles, containing an oxygen or a nitrogen heteroatom, respectively, in the spiro stereocenter, were smoothly obtained with good to excellent diastereoselectivities in high yields.
