1609368-01-5Relevant academic research and scientific papers
Cell-penetrating peptoids: Introduction of novel cationic side chains
K?lmel, Dominik K.,H?rner, Anna,R?nicke, Franziska,Nieger, Martin,Schepers, Ute,Br?se, Stefan
, p. 231 - 243 (2014/05/06)
During the last decade peptoid-based molecular transporters have been broadly applied. They are highly valued for their easy synthesis and their superior stability against enzymatic degradation. The special structure of peptoids generally allows introducing a variety of different side chains. Yet, the cationic side chains of cell-penetrating peptoids displayed solely lysine- or arginine-like structures. Thus this report is intended to extend the spectrum of cationic peptoid side chains. Herein, we present novel functional groups, like polyamines, aza-crown ethers, or triphenylphosphonium ions that are introduced into peptoids for the first time. In addition, the obtained peptoids were tested for their cell-penetrating properties.2014 Published by Elsevier Masson SAS.
