1249429-26-2

Basic information

• Product Name: N-(2-azidoethyl)-N-methylaniline
• Synonyms: N-(2-azidoethyl)-N-methylaniline
• CAS NO: 1249429-26-2
• Molecular Weight: 176.221
• Mol File: 1249429-26-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(2-azidoethyl)-N-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-azidoethyl)-N-methylaniline(1249429-26-2)
• EPA Substance Registry System: N-(2-azidoethyl)-N-methylaniline(1249429-26-2)

Safety Data

• Hazardous Substances Data: 1249429-26-2(Hazardous Substances Data)

Upstream product

• 84877-52-1 2-(methyl(phenyl)amino)ethyl-4-methylbenzenesulfonate 
• 75178-70-0 2-azido-O-methanesulphonyl-ethanol 
• 100-61-8 N-methylaniline 
• 57590-62-2 mesylate derivative 
• 93-90-3 N-(2-hydroxyethyl)-N-methylaminobenzene 

Downstream Products

• 1432151-27-3 C₃₁H₃₂N₉⁽¹⁺⁾*C₂F₃O₂^(1-) 
• 1432152-16-3 C₄₁H₄₀N₉O₂⁽¹⁺⁾*C₂F₃O₂^(1-) 
• 1432152-23-2 C₃₉H₄₁N₁₁O₇S*C₂HF₃O₂ 
• 1609368-01-5 (4-(((2-azidoethyl)methyl)amino)phenyl)bis(4-(dimethylamino)phenyl)methylium chloride 
• 1307899-00-8 4-((2-azidoethyl)(methyl)amino)benzaldehyde 

Relevant articles and documents

Tuning the emission of a water-soluble 3-hydroxyflavone derivative by host-guest complexation

3-Hydroxyflavone derivatives have great potential as fluorescent probes for bio-labeling in aqueous medium. They were extensively studied in various organic solvents for the "excited state intramolecular proton transfer" process, but seldom addressed in aqueous solution due to the poor water solubility. Herein, an amphiphilic molecule bearing 3-hydroxyflavone and oligo(ethylene oxide) (denoted as 3HF-EO) was designed and synthesized. Different from the fluorescence in organic solvents, 3HF-EO in aqueous solution showed a remarkable single fluorescence emission, which is ascribed to the fluorescence of its anionic species. We found that the fluorescence intensity could be efficiently tuned via host-guest complexation. α-CD has little effect on the emission, while β-CD and γ-CD lead to enhanced and reduced emissions of 3HF-EO, respectively. The 1H NMR and 2D NOESY NMR spectra indicate that α-CD barely had any interaction with 3HF-EO, while β-CD and γ-CD formed complexes with one and two 3HF-EO molecules, respectively. These results provide a sound explanation for the modulated fluorescence intensity.

In vitro antiplasmodial activity of triazole-linked chloroquinoline derivatives synthesized from 7-chloro-N-(prop-2-yn-1-yl)quinolin-4-amine

The synthesis and in vitro evaluation of novel triazole-linked chloroquinoline derivatives as potential antiplasmodial agents against Plasmodium falciparum is reported. The 15 synthesized target compounds were obtained by means of a copper(I)-mediated click reaction between a variety of 1,2- and 1,3-azidoamines and 7-chloro-N-(prop-2-yn-1-yl)quinolin-4-amine in moderate to good yields (53-85%). The compounds were screened for antiplasmodial activity against NF54 chloroquine-sensitive and Dd2 chloroquine-resistant strains, alongside chloroquine and artesunate as reference compounds. Six of the test compounds revealed a 3-5 fold increase in antiplasmodial activity against chloroquine-resistant strain Dd2 compared to chloroquine. Among the six compounds with good antiplasmodial activity, a reduced cross-resistance relative to artesunate (>3 fold in comparison to chloroquine) was observed, mainly in derivatives that incorporated chloroquine-resistance reversing pharmacophores. A general trend for reduced chloroquine cross-resistance was also detected among 12 out of the 15 compounds tested.