1609398-91-5

Basic information

• Product Name: 2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester
• Synonyms: 2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester
• CAS NO: 1609398-91-5
• Molecular Weight: 391.463
• Mol File: 1609398-91-5.mol

Chemical Properties

• CAS DataBase Reference: 2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester(1609398-91-5)
• EPA Substance Registry System: 2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester(1609398-91-5)

Safety Data

• Hazardous Substances Data: 1609398-91-5(Hazardous Substances Data)

Upstream product

• 1609398-87-9 (Z)-2-[2-(4-fluorobenzyl)-1,1-dioxido-2H-1,2-benzothiazin-4(3H)-ylidene]acetic acid isopropyl ester 
• 110212-61-8 isopropyl 2-(triphenylphosphoranylidene)acetate 
• 29921-57-1 isopropyl 2-bromoacetate 

Downstream Products

• 1609399-04-3 2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid 

Relevant articles and documents

Copper-catalyzed asymmetric synthesis and comparative aldose reductase inhibition activity of (+)/(-)-1,2-benzothiazine-1,1-dioxide acetic acid derivatives

A copper catalyst system for the asymmetric 1,4-hydrosilylation of the α,β-unsaturated carboxylate class was developed by which synthesis of (+)- and (-)-enantiomers of 1,2-benzothiazine-1,1-dioxide acetates has been achieved with a good yield and an excellent level of enantioselectivity. A comparative structure-activity relationship study yielded the following order of aldose reductase inhibition activity: (-)-enantiomers > racemic > (+)-enantiomers. Further, a molecular docking study suggested that the (-)-enantiomer had significant binding affinity and thus increased inhibition activity.