1609458-95-8Relevant academic research and scientific papers
One-pot regioselective synthesis of β-lactams by a tandem Ugi 4CC/SN cyclization
Zeng, Xiao-Hua,Wang, Hong-Mei,Yan, Yan-Mei,Wu, Lei,Ding, Ming-Wu
, p. 3647 - 3652 (2014)
β-Lactam scaffold was fabricated regioselectively by a facile one-pot base-mediated synthesis. The reactions of bromoacetic acid 1, primary amines 2, isocyanides 3, and arylglyoxals 4 produced 2-aroyl-4-oxoazetidine-2-carboxamides 6 in good yields via a one-pot tandem Ugi condensation and intramolecular C-alkylation at room temperature in the presence of Cs2CO 3.
