1609464-51-8

Basic information

• Product Name: C₂₂H₂₆Cl₂N₄O₄
• CAS NO: 1609464-51-8
• Molecular Weight: 481.379
• Mol File: 1609464-51-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₆Cl₂N₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₆Cl₂N₄O₄(1609464-51-8)
• EPA Substance Registry System: C₂₂H₂₆Cl₂N₄O₄(1609464-51-8)

Safety Data

• Hazardous Substances Data: 1609464-51-8(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 181955-79-3 N,N'-di-tert-butyloxycarbonylpiperazine-2-carboxylic acid 
• 935544-47-1 tert-butyl 3-oxotetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxylate 
• 960535-17-5 tert-butyl 3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate 
• 102-36-3 3,4-dichlorophenylisocyanate 

Relevant articles and documents

Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as α7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders

Herein we report the design, synthesis, and structure-activity relationships for a new class of α7 nicotinic acetylcholine receptor (nAChR) modulators based on the 2-((pyridin-3-yloxy)methyl)piperazine scaffold. The oxazolo[4,5-b]pyridine, (R)-18, and 4-methoxyphenylurea, (R)-47, were identified as potent and selective modulators of the α7 nAChR with favorable in vitro safety profiles and good oral bioavailability in mouse. Both compounds were shown to significantly inhibit cellular infiltration in a murine model of allergic lung inflammation. Despite the structural and in vivo functional similarities in the compounds, only (R)-18 was shown to be an agonist. Compound (R)-47 demonstrated silent agonist activity. These data support the hypothesis that the anti-inflammatory activity of the α7 nAChR is mediated by a signal transduction pathway that is independent of ion current.