16095-45-7

Upstream product

• 50-00-0 formaldehyd 
• 19218-88-3 N-phenyl-4-chloroanthranilic acid 

Downstream Products

• 16075-19-7 7-chloro-1-phenyl-1,2-dihydro-benzo[d][1,3]thiazin-4-one 
• 16075-00-6 7-chloro-1-phenyl-1,2-dihydro-benzo[d][1,3]thiazine-4-thione 
• 16075-05-1 7-chloro-1-phenyl-1,2-dihydro-benzo[d][1,3]oxazine-4-thione 

Relevant academic research and scientific papers

Pd-Catalyzed Intramolecular Chemoselective C(sp2)-H and C(sp3)-H Activation of N-Alkyl- N-arylanthranilic Acids

A controllable palladium-catalyzed intramolecular C-H activation of N-alkyl-N-arylanthranilic acids has been developed. The methodology allows selective synthesis of 1,2-dihydro-(4H)-3,1-benzoxazin-4-ones and carbazoles from the same starting materials and palladium catalyst. The selectivity is controlled by the oxidant. Silver oxide promotes C(sp3)-H activation/C-O cyclization to provide 1,2-dihydro-(4H)-3,1-benzoxazin-4-ones, while copper acetate contributes to C(sp2)-H activation/decarboxylative arylation to afford carbazoles. This protocol is demonstrated by its wide substrate scope and good functional group tolerance.