19218-88-3

Basic information

• Product Name: 4-CHLORO-2-PHENYLAMINO-BENZOIC ACID
• Synonyms: 4-CHLORO-2-PHENYLAMINO-BENZOIC ACID;ART-CHEM-BB B019637
• CAS NO: 19218-88-3
• Molecular Formula: C₁₃H₁₀ClNO₂
• Molecular Weight: 247.68
• Mol File: 19218-88-3.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLORO-2-PHENYLAMINO-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-PHENYLAMINO-BENZOIC ACID(19218-88-3)
• EPA Substance Registry System: 4-CHLORO-2-PHENYLAMINO-BENZOIC ACID(19218-88-3)

Safety Data

• Hazardous Substances Data: 19218-88-3(Hazardous Substances Data)

Upstream product

• 50-84-0 2,4 dichlorobenzoic acid 
• 62-53-3 aniline 
• 32606-06-7 (3,7-dichloro-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-quinolin-3-yl)-acetic acid 
• 71-41-0 pentan-1-ol 
• 13421-13-1 4-chloro-2-iodobenzoic acid 
• 936-08-3 2-bromo-4-chlorobenzoic acid 

Downstream Products

• 195370-32-2 C₁₄H₁₃ClN₄OS 
• 1147303-85-2 6-chloro-8-(N-phenylamino)-3,4-diphenylisocoumarin 
• 1147304-17-3 4-(1,2-diphenylethenyl)-2-chloro-9H-carbazole 
• 31376-66-6 C₁₅H₁₄ClNO₂ 
• 1428865-38-6 4-chloro-2-(methyl(phenyl)amino)benzaldehyde 
• 31376-67-7 C₁₄H₁₄ClNO 
• 58658-41-6 3-chloro-10-methylacridin-9(10H)-one 
• 1418026-00-2 3-aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride 
• 1418025-99-6 3-azidomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester 
• 1418025-86-1 2-bromo-thiazole-5-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)amide 
• 1418024-13-1 6-chloro-N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide 
• 1418025-85-0 3-aminomethyl-7-chloro-1-phenyl-1H-quinolin-4-one 
• 1418025-84-9 3-azidomethyl-7-chloro-1-phenyl-1H-quinolin-4-one 
• 1418026-20-6 3-bromomethyl-7-chloro-1-phenyl-1H-quinolin-4-one 

Relevant articles and documents

Sp2CH?Cl hydrogen bond in the conformational polymorphism of 4-chloro-phenylanthranilic acid

Chlorine can participate in numerous interactions such as halogen bonding, hydrogen bonding, and London dispersion in the solid state. In this work, we report the influence of a chlorine substituent on the polymorphism of a potential anticancer drug, 4-ch

2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS

Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): (IA) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

Light-Driven Intramolecular C?N Cross-Coupling via a Long-Lived Photoactive Photoisomer Complex

Reported herein is a visible-light-driven intramolecular C?N cross-coupling reaction under mild reaction conditions (metal- and photocatalyst-free, at room temperature) via a long-lived photoactive photoisomer complex. This strategy was used to rapidly prepare the N-substituted polycyclic quinazolinone derivatives with a broad substrate scope (>50 examples) and further exploited to synthesize the natural products tryptanthrin, rutaecarpine, and their analogues. The success of gram-scale synthesis and solar-driven transformation, as well as promising tumor-suppressing biological activity, proves the potential of this strategy for practical applications. Mechanistic investigations, including control experiments, DFT calculations, UV-vis spectroscopy, EPR, and X-ray single-crystal structure of the key intermediate, provides insight into the mechanism.