1609532-04-8

Basic information

• Product Name: C₆H₆⁽³⁴⁾S
• Synonyms: C₆H₆⁽³⁴⁾S
• CAS NO: 1609532-04-8
• Molecular Weight: 112.114
• Mol File: 1609532-04-8.mol

Chemical Properties

• CAS DataBase Reference: C₆H₆⁽³⁴⁾S(CAS DataBase Reference)
• NIST Chemistry Reference: C₆H₆⁽³⁴⁾S(1609532-04-8)
• EPA Substance Registry System: C₆H₆⁽³⁴⁾S(1609532-04-8)

Safety Data

• Hazardous Substances Data: 1609532-04-8(Hazardous Substances Data)

Upstream product

• 100-59-4 phenylmagnesium chloride 

Relevant articles and documents

Transformation of a mononitrosyl iron complex to a [2Fe-2S] cluster by a cysteine analogue

Reversible modification of iron-sulfur clusters by nitric oxide acts as a genetic switch in a group of regulatory proteins. While the conversion of [Fe-S] clusters to iron-nitrosyls has been widely studied in the past, little is known about the reverse process, the repair of [Fe-S] clusters. Reported here is a system in which a mononitrosyl iron complex (MNIC), (PPN)[Fe(S tBu)3(NO)] (1), is converted to a [2Fe-2S] cluster, (PPN)2[Fe2S2(SCH2CH 2C(O)OMe)4] (2). This conversion requires only the addition of a cysteine analogue, 3-mercaptomethylpropionate (MMP), at room temperature without the need for any other reagents. The identity of 2 was confirmed spectroscopically, chemically, crystallographically, and analytically. Mass spectrometry and 34S labeling studies support that the bridging sulfides in 2 derive from the added MMP, the cysteine analogue. The NO lost during the conversion of 1 to 2 is trapped in a dinitrosyl iron side product, (PPN)[Fe(SCH2CH2C(O)OMe)2(NO)2] (4). The present system implies that MNICs are likely intermediates in the repair of NO-damaged [2Fe-2S] clusters and that cysteine is a viable molecule responsible for the destabilization of MINCs and the formation of [2Fe-2S] clusters.