1609548-30-2

Basic information

• Product Name: C₃₆H₄₁ClN₄O
• Synonyms: C₃₆H₄₁ClN₄O
• CAS NO: 1609548-30-2
• Molecular Weight: 581.201
• Mol File: 1609548-30-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₆H₄₁ClN₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₄₁ClN₄O(1609548-30-2)
• EPA Substance Registry System: C₃₆H₄₁ClN₄O(1609548-30-2)

Safety Data

• Hazardous Substances Data: 1609548-30-2(Hazardous Substances Data)

Upstream product

• 583-53-9 2,3-dibromobenzene 
• 503536-74-1 5-(4-methylphenyl)pyridin-2-ylamine 
• 1554015-91-6 1-(2-bromophenyl)-4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine] 
• 1554015-89-2 4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine] 

Downstream Products

• 1609548-26-6 C₃₅H₃₉ClN₄O 

Relevant articles and documents

2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists

Blockade of the P2Y1 receptor is important to the treatment of thrombosis with potentially improved safety margins compared with P2Y 12 receptor antagonists. Investigation of a series of urea surrogates of the diaryl urea lead 3 led to the discovery of 2-amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y 1 receptor antagonists, among which compound 5a was the most potent and the first non-urea analog with platelet aggregation (PA) IC50 less than 0.5 μM with 10 μM ADP. Several 2-amino-1,3,4-thiadiazole analogs such as 5b and 5f had a more favorable pharmacokinetic profile, such as higher Ctrough, lower Cl, smaller Vdss, and similar bioavailability compared with 3.