503536-74-1

Basic information

• Product Name: 5-P-TOLYLPYRIDIN-2-YLAMINE
• Synonyms: 5-(4-METHYLPHENYL)-2-PYRIDINAMINE;AKOS BAR-0885;5-P-TOLYLPYRIDIN-2-YLAMINE;5-P-TOLYLPYRIDIN-2-YLAMINE, 95+%;2-Amino-5-(4-tolyl)pyridine;5-(4-Methylphenyl)pyridin-2-aMine;5-(p-Tolyl)pyridin-2-aMine;5-(p-Tolyl)picolinaMide
• CAS NO: 503536-74-1
• Molecular Formula: C₁₂H₁₂N₂
• Molecular Weight: 184.24
• EINECS: 604-604-1
• Mol File: 503536-74-1.mol

Chemical Properties

• Boiling Point: 334.363oC at 760 mmHg
• Flash Point: 182.486oC
• Appearance: /
• Density: 1.107g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 5-P-TOLYLPYRIDIN-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-P-TOLYLPYRIDIN-2-YLAMINE(503536-74-1)
• EPA Substance Registry System: 5-P-TOLYLPYRIDIN-2-YLAMINE(503536-74-1)

Safety Data

• Hazardous Substances Data: 503536-74-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
5-P-Tolylpyridin-2-ylamine is used as a building block for the synthesis of various pharmaceuticals due to its unique chemical properties and reactivity. Its ability to form stable complexes with metal ions makes it a valuable component in the development of new drugs with enhanced efficacy and selectivity.
Used in Agrochemical Synthesis:
In the agrochemical industry, 5-P-Tolylpyridin-2-ylamine serves as a key intermediate in the synthesis of various agrochemicals, such as pesticides and herbicides. Its unique chemical structure allows for the creation of compounds with improved activity and selectivity against target pests and weeds.
Used in Coordination Chemistry:
As a ligand in coordination chemistry, 5-P-Tolylpyridin-2-ylamine is used to form stable complexes with various metal ions. These complexes have potential applications in areas such as catalysis, sensing, and materials science, where the unique properties of the metal-ligand interactions can be exploited for specific functions.
Used in Organic Synthesis:
5-P-Tolylpyridin-2-ylamine is a versatile intermediate in organic synthesis, allowing for the creation of a wide range of organic compounds. Its reactivity and the presence of both tolyl and pyridine groups make it a valuable building block for the synthesis of complex organic molecules with diverse applications.
Used in Research Settings:
In research, 5-P-Tolylpyridin-2-ylamine is utilized for studying its potential biological activities, such as antimicrobial and anti-inflammatory properties. This research can lead to the development of new therapeutic agents and a better understanding of the compound's interactions with biological systems.

InChI:InChI=1/C12H12N2/c1-9-2-4-10(5-3-9)11-6-7-12(13)14-8-11/h2-8H,1H3,(H2,13,14)

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 5720-05-8 4-methylphenylboronic acid 
• 910791-86-5 N-[(3'-bromo-5'-(4''-methylphenyl))pyridin-2-yl]pyridinium aminide 

Downstream Products

• 1044239-25-9 N-[5-(4-methylphenyl)pyridin-2-yl]benzamide 
• 1381942-60-4 3-bromo-5-(4-methylphenyl)-2-pyridinamine 
• 1609548-30-2 C₃₆H₄₁ClN₄O 

Relevant articles and documents

The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors

Leucine-rich repeat kinase 2 (LRRK2) has attracted considerable interest as a therapeutic target for the treatment of Parkinson's disease. Compounds derived from a 2-aminopyridine screening hit were optimised using a LRRK2 homology model based on mixed li

False positives in a reporter gene assay: Identification and synthesis of substituted N-pyridin-2-ylbenzamides as competitive inhibitors of firefly luciferase

Luciferase reporter-gene assays are a commonly used technique in high-throughput screening campaigns. In this study, we report on a luciferase inhibitor (1), which emerged from an antagonistic G protein-coupled receptor luciferase reporter-gene assay scre

A new class of pyrazolopyridine nucleus with fluorescent properties, obtained through either a radical or a Pd arylation pathway from N-azinylpyridinium N-aminides

(Chemical Equation Presented) The synthesis of dipyridopyrazole and pyridopyrazolopyrazine derivatives - both of which incorporate a 3-aryl moiety - can be achieved in moderate yields by intramolecular radical arylation of pyridinium N-aminides using tris(trimethylsilyl)silane and azobisisobutyronitrile. Improved results were obtained on using Pd direct arylation in conjunction with microwave irradiation. A preliminary study into the fluorescent properties of the target compounds is also reported.