1609550-52-8Relevant articles and documents
Structure-based design and synthesis of bicyclic fused-pyridines as MEK inhibitors
Lu, Hejun,Tu, Wangyang,Fei, Hongbo,Xu, Guoji,Hu, Qiyue,Zhang, Lei,Lin, Bing,Yuan, Jijun,Yin, Junzhao,Gong, Aishen,Wan, Mimi,Wang, Dan,Zhu, Xiaoyan,Feng, Jun,Wang, Qian,Sun, Piaoyang
, p. 2555 - 2559 (2014/05/20)
The MAPK pathway is identified as one of the most important pathways involved in cell proliferation and differentiation. A key kinase in the pathway, the Mitogen-activated protein kinase kinase (MEK) is recognized as a promising target for antitumor drugs. Structure-based design and optimization of known MEK inhibitors resulted in identification of compound 10a as a potent non-ATP competitive MEK inhibitor in both in vitro and in vivo tests.
