64224-59-5

Usage

Uses

Used in Organic Synthesis:
Ethyl 5-broMo-4-pyriMidinecarboxylate is used as a building block in the synthesis of various heterocyclic compounds, which are important in pharmaceutical, agrochemical, and materials chemistry. Its versatile reactivity allows for the formation of a wide range of functionalized pyrimidines with potential applications in drug discovery and development.
Used in the Preparation of Heterocyclometallated Complexes:
Ethyl 5-broMo-4-pyriMidinecarboxylate is used as a ligand in the preparation of heterocyclometallated complexes, particularly those involving iridium. These complexes exhibit unique photophysical and electrochemical properties, making them valuable for the development of electroluminescent materials.
Used in OLED Industry:
In the field of organic light-emitting diodes (OLEDs), Ethyl 5-broMo-4-pyriMidinecarboxylate is used as a key component in the synthesis of electroluminescent materials. These materials are crucial for the fabrication of high-performance OLED devices, which are widely used in display technologies, lighting, and other optoelectronic applications.

Upstream product

• 4595-59-9 5-bromopyrimidine 
• 73652-14-9 α-hydroxy-α-(ethoxycarbonyl)ethyl hydroperoxide 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 64224-60-8 5-bromo-4-pyrimidine carboxylic acid 

Downstream Products

• 1609550-60-8 C₁₇H₁₈FIN₄O₃ 
• 1609550-48-2 C₁₄H₁₄FIN₄O₃ 
• 1609550-49-3 C₁₄H₁₄FIN₄O₃ 
• 1609550-46-0 C₁₃H₁₁FIN₃O₂ 
• 1609550-50-6 C₁₃H₁₂FIN₄O₂ 
• 1609550-47-1 C₁₁H₇FIN₃O₂ 
• 1609550-51-7 C₁₄H₁₄FIN₄O₂ 
• 1609550-52-8 C₁₃H₁₂FIN₄O₃ 
• 1609550-53-9 C₁₄H₁₄FIN₄O₄ 
• 1609550-54-0 C₁₄H₁₄FIN₄O₄ 
• 1609550-55-1 C₁₄H₁₄FIN₄O₃ 
• 1609550-45-9 C₁₃H₁₂FN₃O₂ 

Relevant academic research and scientific papers

Structure-based design and synthesis of bicyclic fused-pyridines as MEK inhibitors

The MAPK pathway is identified as one of the most important pathways involved in cell proliferation and differentiation. A key kinase in the pathway, the Mitogen-activated protein kinase kinase (MEK) is recognized as a promising target for antitumor drugs. Structure-based design and optimization of known MEK inhibitors resulted in identification of compound 10a as a potent non-ATP competitive MEK inhibitor in both in vitro and in vivo tests.

A facile synthesis of 5-halopyrimidine-4-carboxylic acid esters via a Minisci reaction

This paper reports the synthesis of various 5-halopyrimidine-4-carboxylic acid esters via the Minisci homolytic alkoxycarbonylation of 5-halopyrimidines. The reaction was found to be highly regioselective, allowing the one-step synthesis of useful amounts

1,2-Dithiole derivatives

1,2-Dithiole derivatives of the formula: STR1 WHEREIN Het represents an aromatic heterocyclic radical with six atoms in the ring two of which are nitrogen atoms, the heterocyclic radical optionally carrying a single substituent selected from halogen, alkyl, alkoxy, mercapto, alkylthio, dialkylamino, pyrrolidin-1-yl, piperidino, morpholino and 4-alkylpiperazin-1-yl and R represents halogen, alkyl (optionally substituted by alkoxycarbonyl), carboxy, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl or a group R1 --C(OH)-- in which R1 represents hydrogen or alkyl, the said alkyl, alkoxy and alkylthio radicals or alkyl or alkoxy moieties containing 1 to 4 carbon atoms except in the case of R1 which contains 1 to 3 carbon atoms when an alkyl radical, are new compounds useful in the treatment of bilharziasis.