1609554-63-3Relevant academic research and scientific papers
Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer
Zhang, Yong,Seigal, Benjamin A.,Terrett, Nicholas K.,Talbott, Randy L.,Fargnoli, Joseph,Naglich, Joseph G.,Chaudhry, Charu,Posy, Shana L.,Vuppugalla, Ragini,Cornelius, Georgia,Lei, Ming,Wang, Chunlei,Zhang, Yingru,Schmidt, Robert J.,Wei, Donna D.,Miller, Michael M.,Allen, Martin P.,Li, Ling,Carter, Percy H.,Vite, Gregory D.,Borzilleri, Robert M.
, p. 770 - 775 (2015/07/15)
A series of dimeric macrocyclic compounds were prepared and evaluated as antagonists for inhibitor of apoptosis proteins. The most potent analogue 11, which binds to XIAP and c-IAP proteins with high affinity and induces caspase-3 activation and ultimatel
MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS
-
, (2014/05/24)
There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS
-
Page/Page column, (2014/05/20)
There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, util
