1609561-64-9Relevant academic research and scientific papers
Synthesis of Thieno [2,3-d] imidazoles by copper-catalyzed amidine cyclization
Liubchak, Kostiantyn,Tolmachev, Andrey,Nazarenko, Kostiantyn
supporting information, p. 965 - 968 (2014/05/06)
A new synthetic approach to thieno[2,3-d]imidazoles is presented on the basis of the N′-(3-halothiophen-2-yl)amidine cyclization under copper-catalyzed cross-coupling. Using commercially available starting materials such as 2-aminothiophenes or their Boc-protected derivatives and copper catalysts, this method offers a convenient route to a wide range of thieno[2,3-d]imidazole derivatives, especially the 5-alkyl-subtituted thieno[2,3-d]imidazoles. Georg Thieme Verlag Stuttgart - New York.
