1609565-45-8

Basic information

• Product Name: 2,4-difluoro-N-(5-(imidazo[1,2-a]pyridin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide
• Synonyms: 2,4-difluoro-N-(5-(imidazo[1,2-a]pyridin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide
• CAS NO: 1609565-45-8
• Molecular Weight: 416.408
• Mol File: 1609565-45-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4-difluoro-N-(5-(imidazo[1,2-a]pyridin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-difluoro-N-(5-(imidazo[1,2-a]pyridin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide(1609565-45-8)
• EPA Substance Registry System: 2,4-difluoro-N-(5-(imidazo[1,2-a]pyridin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide(1609565-45-8)

Safety Data

• Hazardous Substances Data: 1609565-45-8(Hazardous Substances Data)

Upstream product

• 1086063-46-8 N-(5-bromo-2-methoxypyridine-3-yl)-2,4-difluorobenzene sulfonyl chloride 
• 13918-92-8 2,4-difluorobenzene-1-sulfonyl chloride 
• 884495-39-0 5-bromo-2-(methyloxy)-3-pyridinamine 
• 1083326-73-1 N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide 
• 6188-23-4 6-bromoimidazo[1,2-a]pyridine 
• 1072-97-5 5-bromo-2-pyridylamine 

Downstream Products

• 1609565-47-0 2,4-difluoro N-(5-(3-(3-hydroxybut-1-yn-1-yl)imidazo[1,2-a]pyridin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide 
• 1609565-49-2 2,4-difluoro-N-(2-methoxy-5-(3-(prop-1-yn-1-yl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)benzenesulfonamide 
• 1609565-48-1 2,4-difluoro-N-(5-(3-(3-hydroxy-3-methylbut-1-yn-1-yl)imidazo[1,2-a]pyridin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide 
• 1609565-44-7 2,4-difluoro-N-(5-(3-(3-hydroxyprop-1-yn-1-yl)imidazo[1,2-a]pyridin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide 
• 1609565-46-9 2,4-difluoro-N-(5-(3-iodoimidazo[1,2-a]pyridin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Imidazo[1,2- a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors

PI3K-Akt-mTOR signaling pathway has been validated as an effective targeting pathway for cancer therapy. However, no PI3K/mTOR dual inhibitor has been approved by the FDA yet. Therefore, it is still essential to discover a candidate with good efficacy and low toxicity. In our design, a series of imidazo[1,2-a]pyridine derivatives had been synthesized and subjected to activity assessment in vitro and in vivo. 15a was proved to be a potent PI3K/mTOR dual inhibitor with excellent kinase selectivity, modest plasma clearance, and acceptable oral bioavailability. Besides, 15a displayed significant inhibition of tumor growth in HCT116 and HT-29 xenografts without obvious effect on body weight.

HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS AND METHODS OF USE

The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.