1609623-93-9Relevant articles and documents
Organocatalytic cascade reactions: Diversity-oriented synthesis for the construction of hydroisoquinoline scaffolds
Gómez, Clarisa Villegas,Cruz, David Cruz,Mose, Rasmus,J?rgensen, Karl Anker
supporting information, p. 6035 - 6038 (2014/05/20)
The organocatalytic enantioselective synthesis of highly functionalized hydroisoquinolines by trienamine-mediated [4+2]-cycloaddition/nucleophilic ring-closing reaction cascade sequence of cyanoacrylamides with 2,4-dienals is presented. The corresponding cycloadducts are formed in high yields and excellent stereoselectivities. Moreover, a series of transformations demonstrate the synthetic application of the obtained hydroisoquinolines. the Partner Organisations 2014.