1609627-36-2Relevant academic research and scientific papers
Indium trichloride catalysed domino reactions of isatin: A facile access to the synthesis of spiro(indoline-3,4′-pyrano[2,3- c ]pyrazol)-2-one derivatives
Poomathi, Nataraj,Kamalraja, Jayabal,Mayakrishnan, Sivakalai,Muralidharan,Perumal, Paramasivan T.
, p. 708 - 712 (2014)
A versatile high-yielding indium trichloride mediated one-pot regioselective synthesis of spiroxindoles via domino one-pot, three-component reaction of isatins, pyrazoles, and (E-)-N-methyl-1-(methylthio)-2- nitroethenamine is described. This reaction presumably occurs via domino Knoevenagel condensation-?Michael addition-intramolecular O-cyclization sequence. The salient features of the methodology are its clean reaction conditions, the eco-friendly medium, low cost, easy isolation, and excellent yields without column chromatographic purification. Georg Thieme Verlag Stuttgart. New York.
