1609636-92-1

Basic information

• Product Name: 2-benzyl-3,4,11,11a-tetrahydro-2H,6H-pyrazino[1,2-b]isoquinoline-1,7,10-trione
• Synonyms: 2-benzyl-3,4,11,11a-tetrahydro-2H,6H-pyrazino[1,2-b]isoquinoline-1,7,10-trione
• CAS NO: 1609636-92-1
• Molecular Weight: 322.364
• Mol File: 1609636-92-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-benzyl-3,4,11,11a-tetrahydro-2H,6H-pyrazino[1,2-b]isoquinoline-1,7,10-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-3,4,11,11a-tetrahydro-2H,6H-pyrazino[1,2-b]isoquinoline-1,7,10-trione(1609636-92-1)
• EPA Substance Registry System: 2-benzyl-3,4,11,11a-tetrahydro-2H,6H-pyrazino[1,2-b]isoquinoline-1,7,10-trione(1609636-92-1)

Safety Data

• Hazardous Substances Data: 1609636-92-1(Hazardous Substances Data)

Upstream product

• 198021-01-1 ethyl 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 19164-83-1 1,4-dimethoxy-2,3-bis(bromomethyl)benzene 
• 1609636-84-1 7,10-dimethoxy-2-benzyl-3,4,11,11a-tetrahydro-2H,6H-pyrazino[1,2-b]isoquinolin-1-one 
• 1609636-60-3 ethyl 2-(2-bromoethyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 

Relevant articles and documents

Synthesis of hexahydropyrazino[1,2-b]isoquinolines as simplified saframycin analogues

Various hexahydropyrazino[1,2-b]isoquinolines were synthesised as simplified saframycin analogues. Construction of this core proceeded through a tetrahydroisoquinoline synthesis followed by acylation/alkylation of the tetrahydroisoquinoline nitrogen and subsequent ring closure using various aliphatic and aromatic amines. The resulting piperazinones were reacted with LiAlH4 or LiAlH(OEt)3 to synthesise further analogues. Georg Thieme Verlag Stuttgart · New York.