115378-33-1

Basic information

• Product Name: Carbamic acid, [(1S)-1-methyl-2-propenyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [(1S)-1-methyl-2-propenyl]-, 1,1-dimethylethyl ester (9CI)
• CAS NO: 115378-33-1
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.23678
• Product Categories: N-BOC
• Mol File: 115378-33-1.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(1S)-1-methyl-2-propenyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-methyl-2-propenyl]-, 1,1-dimethylethyl ester (9CI)(115378-33-1)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-methyl-2-propenyl]-, 1,1-dimethylethyl ester (9CI)(115378-33-1)

Safety Data

• Hazardous Substances Data: 115378-33-1(Hazardous Substances Data)

Upstream product

• 75-11-6 diiodomethane 
• 79069-50-4 Boc-Ala-H 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 28875-17-4 (S)-N-(tert-butoxycarbonyl)alanine methyl ester 
• 1033286-96-2 (S)-tert-butyl formyl(1-methylprop-2-en-1-yl)carbamate 
• 913344-40-8 tert-butyl N-formyl carbamate 
• 129076-07-9 (-)-di-tert-butyl [(1S)-1-methylprop-2-en-1-yl]imidodicarbonate 
• 154079-54-6 (2S,3S)-3-tert-butoxycarbonylamino-1,2-butanediol 

Downstream Products

• 1609651-47-9 C₂₂H₂₄FN₃O₂ 
• 106539-14-4 (S)-methyl 3-(tert-butyloxycarbonylamino)butyrate 
• 357385-69-4 1(R,S)-[1'(S)-tert-butyloxycarbonylaminoethyl]oxirane 
• 106539-36-0 tert-butyl N-[(2S)-4-hydroxybutan-2-yl]carbamate 
• 79069-13-9 (S)-2-t-butoxycarbonylaminopropan-1-ol 

Relevant articles and documents

Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease

Therapeutic reactivation of the γ-globin genes for fetal hemoglobin (HbF) production is an attractive strategy for treating β-thalassemia and sickle cell disease. It was reported that genetic knockdown of the histone lysine methyltransferase EHMT2/1 (G9a/GLP) is sufficient to induce HbF production. The aim of the present work was to acquire a G9a/GLP inhibitor that induces HbF production sufficiently. It was revealed that tetrahydroazepine has versatility as a side chain in various skeletons. We ultimately obtained a promising aminoindole derivative (DS79932728), a potent and orally bioavailable G9a/GLP inhibitor that was found to induce γ-globin production in a phlebotomized cynomolgus monkey model. This work could facilitate the development of effective new approaches for treating β-thalassemia and sickle cell disease.

AMINO SULFONYL COMPOUNDS

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

Iridium-catalyzed asymmetric allylic substitutions with bulky amines/oxidative double bond cleavage - Entry into the reetz synthesis of amino alcohols

Branched allylic amines were prepared by Ir-catalyzed enantioselective allylic aminations with the bulky N-nucleophiles HN(Boc)2 and HNBn2. The products were transformed into N-protected amino aldehydes, which were either reduced or coupled diastereoselectively with organometallic compounds to give vicinal amino alcohols. A formal synthesis of the neurokinin receptor antagonist (+)-L-733060 was carried out as an application. Ir-catalyzed enantioselective allylic aminations with bulky N-nucleophiles HN(Boc)2 and HNBn2 gave N-protected allylic amines, which were transformed into N-protected chiral amino aldehydes. These are useful chiral building blocks as previously demonstrated by Reetz et al. A formal synthesis of the neurokinin receptor antagonist (+)-L-733060 was carried out as an application.