1609686-94-3

Basic information

• Product Name: (E)-methyl 4-{6-[4-(2-cyanovinyl)-2,6-dimethylphenylamino]-3-fluoropyridin-2-ylamino}benzoate
• CAS NO: 1609686-94-3
• Molecular Weight: 416.455
• Mol File: 1609686-94-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-methyl 4-{6-[4-(2-cyanovinyl)-2,6-dimethylphenylamino]-3-fluoropyridin-2-ylamino}benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-methyl 4-{6-[4-(2-cyanovinyl)-2,6-dimethylphenylamino]-3-fluoropyridin-2-ylamino}benzoate(1609686-94-3)
• EPA Substance Registry System: (E)-methyl 4-{6-[4-(2-cyanovinyl)-2,6-dimethylphenylamino]-3-fluoropyridin-2-ylamino}benzoate(1609686-94-3)

Safety Data

• Hazardous Substances Data: 1609686-94-3(Hazardous Substances Data)

Upstream product

• 52208-50-1 2,6-dichloro-3-fluoropyridine 
• 619-45-4 4-methoxycarbonyl aniline 
• 500292-86-4 3-(4-amino-3,5-dimethylphenyl)acrylonitrile 
• 1609687-14-0 methyl 4-[(6-chloro-3-fluoropyridin-2-yl)amino]benzoate 
• 24596-19-8 4-bromo-2,6-dimethylphenylamine 

Relevant articles and documents

2,6-Di(arylamino)-3-fluoropyridine Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors

New non-nucleoside reverse transcriptase inhibitors (NNRTI), which are similar in structure to earlier described di(arylamino)pyrimidines but featuring a 2,6-di(arylamino)-3-fluoropyridine, 2,4-di(arylamino)-5-fluoropyrimidine, or 1,3-di(arylamino)-4-fluorobenzene moiety instead of a 2,4-disubstituted pyrimidine moiety, are reported. The short and practical synthesis of novel NNRTI relies on two sequential Pd-catalyzed aminations as the key steps. It is demonstrated through direct comparison with reference compounds that the presence of a fluorine atom increases the in vitro anti-HIV activity, both against the wild type virus and drug-resistant mutant strains.