52208-50-1

Basic information

• Product Name: 2,6-Dichloro-3-fluoropyridine
• Synonyms: 2,6-Dichloro-3-fluoropyridine
• CAS NO: 52208-50-1
• Molecular Formula: C₅H₂Cl₂FN
• Molecular Weight: 165.98
• Product Categories: Fluorine series
• Mol File: 52208-50-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 44-46°C
• Boiling Point: 196.034 °C at 760 mmHg
• Flash Point: 72.359 °C
• Appearance: White solid
• Density: 1.498g/cm3
• Vapor Pressure: 0.571mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.21±0.10(Predicted)
• CAS DataBase Reference: 2,6-Dichloro-3-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-3-fluoropyridine(52208-50-1)
• EPA Substance Registry System: 2,6-Dichloro-3-fluoropyridine(52208-50-1)

Safety Data

• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 52208-50-1(Hazardous Substances Data)

Usage

Synthesis

The venerable Balz and Schiemann reaction is the most powerful methodology for preparing aryl fluorides. Not surprisingly, this reaction has been applied to the synthesis of fluoropyridines. Thus, 2,6-dichloro-3-fluoropyridine is readily prepared from 3-amino-2,6-dichloropyridine. The method has been applied to combinatorial synthesis on the solid phase.

InChI:InChI=1/C5H2Cl2FN/c6-4-2-1-3(8)5(7)9-4/h1-2H

Upstream product

• 62476-56-6 3-amino-2,6-dichloropyridine 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 

Downstream Products

• 1609686-94-3 (E)-methyl 4-{6-[4-(2-cyanovinyl)-2,6-dimethylphenylamino]-3-fluoropyridin-2-ylamino}benzoate 
• 1609687-11-7 6-chloro-N-(4-chlorophenyl)-3-fluoropyridin-2-amine 
• 1609686-92-1 4-[6-(4-cyanophenylamino)-5-fluoropyridin-2-yl]amino-3-fluoro-5-methylbenzonitrile 
• 1609686-91-0 4-{6-[4-(2-cyanovinyl)-2-methylphenylamino]-3-fluoropyridin-2-ylamino}benzonitrile 
• 1609687-22-0 4-{6-[4-(2-cyanovinyl)-2-methylphenylamino]-3-fluoropyridin-2-ylamino}benzonitrile 
• 1609686-90-9 (E)-3-(4-{5-fluoro-6-[(4-fluorophenyl)amino]pyridin-2-ylamino}-3-methylphenyl)acrylonitrile 
• 1609686-89-6 (E)-methyl 3-{4-[6-(4-chlorophenylamino)-5-fluoropyridin-2-ylamino]-3,5-dimethylphenyl}acrylate 

Relevant articles and documents

PREPARATION OF NEW 2-CHLORO-5-FLUORO-6-(4-PHENYL-METHYLPIPERAZINYL)-4-TRIFLUOROMETHYL-3-NICOTINIC ACID

The nicotinic acid (15), which could be a key intermediate for novel potential antibacterial 1,8-naphthyridine-3-carboxylic acid analogues, was prepared initiating with construction of the pyridine nucleus by ethyl 2-fluoroacetate and ethyl 2-trifluoroacetate.

Method for preparing 2,5-dihalo- and 2,5,6-trihalopyridines

A method for preparing 2,5-dihalo- and 2,5,6-trihalopyridines corresponding to the formula SPC1 Wherein each X independently represents chloro, fluoro or bromo and R represents hydrogen, chloro, fluoro or bromo which comprises reacting a halohydrazinopyridine of one of the formulas SPC2 With an excess of an aqueous alkali metal hydroxide in the presence of a reaction medium from the group consisting of loweralkanols of 1 to 4 carbon atoms and loweralkylglycols of 2 to 4 carbon atoms.