1609694-06-5Relevant academic research and scientific papers
Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds
Chen, Yi,Yu, Kun,Tan, Nian-Yuan,Qiu, Ren-Hua,Liu, Wei,Luo, Ning-Lin,Tong, Le,Au, Chak-Tong,Luo, Zi-Qiang,Yin, Shuang-Feng
, p. 391 - 398 (2014/05/06)
Three heterocyclic hypervalent organoantimony chlorides RN(CH 2C6H4)2SbCl (2a R = t-Bu, 2b R = Cy, 2c R = Ph) and their chalcogenide derivatives [RN(CH2C 6H4)2Sb]2O (3a R = t-Bu, 3b R = Cy, 3c R = Ph) were synthesized and characterized by techniques such as 1H NMR, 13C NMR, X-ray diffraction, and elemental analysis. It is found that the anti-proliferative activity detected over these compounds can be attributed to the coordination bond between the antimony and nitrogen atoms of these compounds. Moreover, a preliminary study on mechanistic action suggests that the inhibition effect is ascribable to cell cycle arrest and cell apoptosis.
