1609694-04-3

Basic information

• Product Name: 12-chloro-6-phenyl-5,6,7,12-tetrahydrodibenzo[c,f ][1,5]azastibocine
• Synonyms: 12-chloro-6-phenyl-5,6,7,12-tetrahydrodibenzo[c,f ][1,5]azastibocine
• CAS NO: 1609694-04-3
• Molecular Weight: 428.565
• Mol File: 1609694-04-3.mol

Chemical Properties

• CAS DataBase Reference: 12-chloro-6-phenyl-5,6,7,12-tetrahydrodibenzo[c,f ][1,5]azastibocine(CAS DataBase Reference)
• NIST Chemistry Reference: 12-chloro-6-phenyl-5,6,7,12-tetrahydrodibenzo[c,f ][1,5]azastibocine(1609694-04-3)
• EPA Substance Registry System: 12-chloro-6-phenyl-5,6,7,12-tetrahydrodibenzo[c,f ][1,5]azastibocine(1609694-04-3)

Safety Data

• Hazardous Substances Data: 1609694-04-3(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 904689-24-3 N,N-bis(2-bromobenzyl)-N-phenylamine 
• 10025-91-9 antimony(III) chloride 

Downstream Products

• 1609694-06-5 [PhN(CH₂C₆H₄)₂Sb]₂O 

Relevant articles and documents

Nickel- and Palladium-Catalyzed Cross-Coupling Reactions of Organostibines with Organoboronic Acids

A strategy for the formation of antimony-carbon bond was developed by nickel-catalyzed cross-coupling of halostibines. This method has been applied to the synthesis of various triaryl- and diarylalkylstibines from the corresponding cyclic and acyclic halostibines. This protocol showed a wide substrate scope (72 examples) and was compatible to a wide range of functional groups such as aldehyde, ketone, alkene, alkyne, haloarenes (F, Cl, Br, I), and heteroarenes. A successful synthesis of arylated stibine 3 a in a scale of 34.77 g demonstrates high synthetic potential of this transformation. The formed stibines (R3Sb) were then used for the palladium-catalyzed carbon–carbon bond forming reaction with aryl boronic acids [R?B(OH)2], giving biaryls with high selectivity, even the structures of two organomoieties (R and R′) are very similar. Plausible catalytic pathways were proposed based on control experiments.

Organoantimony(III)halide complexes with azastibocine framework as potential antitumor agents: Correlation between cytotoxic activity and N→Sb inter-coordination

The relationship between chemical structure and in vitro cytotoxic activities of a series of azastibocine-framework organoantimony(III)halide complexes against cancerous (HepG2, MDA-MB-231, MCF-7 and HeLa)and nonmalignant (HEK-293)cell lines was studied f

Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds

Three heterocyclic hypervalent organoantimony chlorides RN(CH 2C6H4)2SbCl (2a R = t-Bu, 2b R = Cy, 2c R = Ph) and their chalcogenide derivatives [RN(CH2C 6H4)2Sb]2O (3a R = t-Bu, 3b R = Cy, 3c R = Ph) were synthesized and characterized by techniques such as 1H NMR, 13C NMR, X-ray diffraction, and elemental analysis. It is found that the anti-proliferative activity detected over these compounds can be attributed to the coordination bond between the antimony and nitrogen atoms of these compounds. Moreover, a preliminary study on mechanistic action suggests that the inhibition effect is ascribable to cell cycle arrest and cell apoptosis.