160971-55-1Relevant academic research and scientific papers
Synthesis and Structure-Activity Relationships of Peptidyl α-Keto Heterocycles as Novel Inhibitors of Prolyl Endopeptidase
Tsutsumi, Seiji,Okonogi, Tsuneo,Shibahara, Seiji,Ohuchi, Shokichi,Hatsushiba, Emiko,et al.
, p. 3492 - 3502 (1994)
The preparation and in vitro prolyl endopeptidase (PEP) inhibitory activity of a series of α-keto heterocyclic compounds is described.The design is based on the introduction of α-keto heterocycles at the C-terminal end of substrate-like peptides.Many of t
