Synthesis and Structure-Activity Relationships of Peptidyl α-Keto Heterocycles as Novel Inhibitors of Prolyl Endopeptidase

Article abstract of DOI:10.1021/jm00047a007

The preparation and in vitro prolyl endopeptidase (PEP) inhibitory activity of a series of α-keto heterocyclic compounds is described.The design is based on the introduction of α-keto heterocycles at the C-terminal end of substrate-like peptides.Many of t