1609735-00-3

Upstream product

• 253-82-7 quinazoline 
• 53097-55-5 N-(cyclohexaneylidenemethylene)-1-(1,1-dimethylethyl)-1,1-dimethylsilanamine 
• 1609734-98-6 2-(3,4-dihydroquinazolin-4-yl)-2-methylpropanenitrile 
• 766-05-2 cyclohexane carbonitrile 

Relevant academic research and scientific papers

Azine Activation via Silylium Catalysis

Practical, efficient, and general methods for the diversification of N-heterocycles have been a recurrent goal in chemical synthesis due to the ubiquitous influence of these motifs within bioactive frameworks. Here, we describe a direct, catalytic, and selective functionalization of azines via silylium activation. Our catalyst design enables mild conditions and a remarkable functional group tolerance in a one-pot setup.

Addition of α-lithiated nitriles to azaheterocycles

The addition of α-deprotonated nitriles to azaheteroA?-cycles followed by rearomatization is described. A simple two-step, one-pot procedure for the sequence is also presented. Georg Thieme Verlag Stuttgart New York.