160982-11-6

Basic information

• Product Name: 3-(2-Bromoacetyl)-5-chloro-2-thiophenesulfonamide
• Synonyms: 2-ThiophenesulfonaMide,3-(2-broMoacetyl)-5-chloro-;3-(2-Bromoacetyl)-5-chloro-2-thiophenesulfomide;3-(2-Bromoacetyl)-5-chloro-2-thiophenesulfonamide;3-(Bromoacetyl)-5-chloro-2-thiophenesulfonamide;3-(2-BroMoacetyl)-5-chlorothiophene-2-sulfonaMide
• CAS NO: 160982-11-6
• Molecular Formula: C6H5BrClNO3S2
• Molecular Weight: 318.599
• EINECS: 1312995-182-4
• Mol File: 160982-11-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 492.247 °C at 760 mmHg
• Flash Point: 251.502 °C
• Appearance: /
• Density: 1.936
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.21±0.60(Predicted)
• CAS DataBase Reference: 3-(2-Bromoacetyl)-5-chloro-2-thiophenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Bromoacetyl)-5-chloro-2-thiophenesulfonamide(160982-11-6)
• EPA Substance Registry System: 3-(2-Bromoacetyl)-5-chloro-2-thiophenesulfonamide(160982-11-6)

Safety Data

• Hazardous Substances Data: 160982-11-6(Hazardous Substances Data)

Usage

General Description

3-(2-Bromoacetyl)-5-chloro-2-thiophenesulfonamide is a chemical compound used in pharmaceutical research and development due to its potential biological activities. Its structure consists of a thiophene ring with a chlorine atom at the 5-position and a sulfonamide group at the 2-position. Additionally, there is a bromoacetyl group attached to the thiophene ring, adding to its reactivity and potential for drug interactions. 3-(2-Bromoacetyl)-5-chloro-2-thiophenesulfonamide may be utilized in the synthesis of novel drugs for various therapeutic applications, including antibacterial, antifungal, and anticancer treatments. Its unique structure and potential pharmacological properties make it a valuable compound for further investigation and development in the pharmaceutical industry.

InChI:InChI=1/C6H5BrClNO3S2/c7-2-4(10)3-1-5(8)13-6(3)14(9,11)12/h1H,2H2,(H2,9,11,12)

Upstream product

• 160982-09-2 3-Acetyl-2-(phenylmethyl)thio-5-chlorothiophene 
• 36157-40-1 3-acetyl-2,5-dichlorothiophene 
• 160982-10-5 3-acetyl-5-chloro-2-thiophenesulfonamide 

Downstream Products

• 160982-16-1 (S)-3,4-dihydro-6-chloro-4-hydroxy-4H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide 
• 138890-62-7 brinzolamide 
• 160982-13-8 (S)-3,4-dihydro-6-chloro-4-hydroxy-2-(3-methoxypropyl)-4H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide 
• 154127-42-1 (S)-3,4-dihydro-4-hydroxy-2(3-methoxypropyl)-4H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide 
• 1397689-14-3 4-(5-chloro-2-sulfonamidothien-3-yl)-2-[(2-methylphenoxymethyl)phenyl]-[1,3]-thiazole 
• 1397689-17-6 (5-chloro-2-sulfonamidothien-3-yl)-2-[(4-chlorophenoxymethyl)phenyl]-[1,3]-thiazole 
• 1397689-16-5 4-(5-chloro-2-sulfonamidothien-3-yl)-2-[(4-methylphenoxymethyl)phenyl]-[1,3]-thiazole 
• 1397689-15-4 C₂₁H₁₇ClN₂O₃S₃ 

Relevant articles and documents

Method for preparing 3-bromoacetyl-5-chloro-2-thiophenylsulfonamide

The invention belongs to the technical field of pharmaceutical chemicals and particularly relates to a method for preparing an intermediate of Brinzolamide, i.e., 3-bromoacetyl-5-chloro-2-thiophenylsulfonamide. The method comprises the following steps: subjecting 3-acetyl-5-chloro-2-thiophenyl sulfonamide, which serves as a raw material, and N-bromosuccinimide, which serves as a bromination reagent, to temperature-controlled heating until the raw material reacts completely, concentrating a solvent, and then, carrying out crystallization; and adding solids obtained through centrifugation into water, carrying out pulping, carrying out centrifugation again, and then, carrying out baking, thereby obtaining the 3-bromoacetyl-5-chloro-2-thiophenylsulfonamide. According to the method, the operation is simple and convenient, the production is environmentally friendly, and the obtained product is relatively high in yield, so that the method is more applicable to large-scale production.

Sulfonamides useful as carbonic anhydrase inhibitors

Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.