1609930-01-9

Upstream product

• 112-45-8 10-Undecenal 
• 57-11-4 stearic acid 
• 1609930-15-5 1-(cyclohexylamino)-1-oxododec-11-en-2-yl stearate 
• 119072-55-8 tert-butylisonitrile 
• 1609930-00-8 3-((12-(cyclohexylamino)-12-oxo-11-(stearoyloxy)dodecyl)thio)propanoic acid 
• 931-53-3 Cyclohexyl isocyanide 

Downstream Products

• 1609930-02-0 15-(t-butylcarbamoyl)-31-(cyclohexylcarbamoyl)-17,33-dioxo-16,32-dioxa-4,20-dithiapentacontan-1-oic acid 
• 1609930-03-1 24-(t-butylcarbamoyl)-41-(cyclohexylamino)-8-(dec-9-en-1-yl)-7,10,26,41-tetraoxo-9,25-dioxa-13,29-dithia-6-azahentetracontan-40-yl stearate 
• 1609930-04-2 5-((3-((12-(cyclohexylamino)-12-oxo-11-(stearoyloxy)dodecyl)thio)propanoyl)oxy)-2,2-dimethyl-4,19-dioxo-21-(pentylcarbamoyl)-20-oxa-16,32-dithia-3-azapentatriacontan-35-oic acid 

Relevant academic research and scientific papers

Sequence control in polymer chemistry through the Passerini three-component reaction

A new strategy to achieve sequence control in polymer chemistry based on the iterative application of the versatile Passerini three-component reaction (P-3CR) in combination with efficient thiol-ene addition reactions is introduced. First, stearic acid was used as a starting substrate to build up a sequence-defined tetramer with a molecular weight of 1.6 kDa. Using an acid-functionalized PEG allowed for an easier isolation of the sequence-defined macromolecules by simple precipitation and led to a sequence-defined pentamer in a block-copolymer architecture. Importantly, this new strategy completely avoids protecting group chemistry. By following this strategy, a different side chain can be introduced to the polymer/oligomer backbone in a simple way and at a defined position within the macromolecule. The iterative application of the Passerini three-component reaction and the thiol-ene addition reaction provides sequence-defined macromolecules without the utilization of any protecting group. Copyright