1609931-58-9Relevant academic research and scientific papers
Efficient functionalization of oligonucleotides by new achiral nonnucleosidic monomers
Kupryushkin, Maxim S.,Nekrasov, Mikhail D.,Stetsenko, Dmitry A.,Pyshnyi, Dmitrii V.
, p. 2842 - 2845 (2014/06/23)
A novel synthetic strategy has been designed for preparation of achiral nonnucleosidic phosphoramidite monomers for automated solid-phase oligonucleotide synthesis. It is based on O-DMTr-protected 4-(2-hydroxyethyl)- morpholine-2,3-dione as the key compound and a family of building blocks obtained by its ring-opening by primary aliphatic amines. A series of nonnucleosidic phosphoramidites containing various side-chain functionalities was synthesized, and corresponding oligodeoxyribonucleotides incorporating modified units in single or multiple positions along the chain were prepared.
