1609944-98-0Relevant academic research and scientific papers
DABCO promoted regioselective synthesis of new diversely functionalized 3-hydroxy-2-oxindole scaffolds
Thakur, Pramod B.,Nanubolu, Jagdeesh B.,Meshram, Harshadas M.
, p. 768 - 776 (2014)
An efficient and highly regioselective γ-addition of β-keto sulfones on isatins has been achieved in the presence of a catalytic amount of 1,4-diazabicyclo[2.2.2]octane (DABCO) to afford a γ-(3-hydroxy-2-oxindole) -β-keto sulfone structural framework. The scope of the method is tested by screening a series of isatin electrophiles as well as β-keto sulfones. The described method was found to be very handy and provides straightforward access for the diversely functionalized 3-β-keto sulfone substituted-3-hydroxy-2- oxindole structural scaffolds in very good yields from readily available starting materials under metal-free reaction conditions. CSIRO 2014.
