1609955-67-0

Basic information

• Product Name: C₅₇H₁₀₀ClN₇O₁₀
• CAS NO: 1609955-67-0
• Molecular Weight: 1078.91
• Mol File: 1609955-67-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₇H₁₀₀ClN₇O₁₀(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₇H₁₀₀ClN₇O₁₀(1609955-67-0)
• EPA Substance Registry System: C₅₇H₁₀₀ClN₇O₁₀(1609955-67-0)

Safety Data

• Hazardous Substances Data: 1609955-67-0(Hazardous Substances Data)

Upstream product

• 247193-74-4 2-(4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid 
• 54613-99-9 Boc-(S)-Lys(2-Cl-Z)-OH 
• 124-30-1 1-aminooctadecane 
• 1609955-62-5 C₃₇H₆₄ClN₃O₅ 

Relevant articles and documents

Synthesis and gene transfection activity of cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails

A series of novel 1,4,7,10-tetraazacyclododecane (cyclen)-based cationic lipids with asymmetric double hydrophobic tails (cholesteryl and long aliphatic chains) were designed and synthesized. Lysine was chosen as a linking moiety in the molecular backbone. The liposomes formed from 8 and dioleoylphosphatidylethanolamine (DOPE) could bind and condense plasmid DNA into nanoparticles under a low N/P ratio. These nano-scaled lipoplexes have low cytotoxicity, and might efficiently transfect A549 cells. In vitro transfection results revealed that all cationic lipids showed a comparable or better transfection efficiency (TE) than commercially available Lipofectamine 2000. The length and saturation degree of the aliphatic chain would affect their gene transfection performance, and the linoleic acid-containing 8e could give the best TE. the Partner Organisations 2014.