1609984-67-9

Upstream product

• 1609984-68-0 (E)-ethyl 3-(3,4-bis(benzyloxy)-2,5-dimethylphenyl)acrylate 
• 97073-45-5 3,4-bis(benzyloxy)-2,5-dimethylbenzaldehyde 
• 25163-62-6 3,6-bis-morpholin-4-ylmethyl-benzene-1,2-diol 
• 100-39-0 benzyl bromide 
• 97073-42-2 3,4-dihydroxy-2,5-dimethylbenzaldehyde 
• 2785-78-6 3,6-Dimethylcatechol 
• 120-80-9 benzene-1,2-diol 

Downstream Products

• 1609984-69-1 C₄₅H₄₂O₅ 

Relevant academic research and scientific papers

Synthesis and radical-scavenging activity of a dimethyl catechin analogue

Catechin analogue 1 with methyl substituents ortho to the catechol hydroxyl groups was synthesized to improve the antioxidant ability of (+)-catechin. The synthetic scheme involved a solid acid catalyzed Friedel-Crafts coupling of a cinnamyl alcohol derivative to 3,5-dibenzyloxyphenol followed by hydroxylation and then cyclization through an intermediate orthoester. The antioxidative radical scavenging activity of 1 against galvinoxyl radical, an oxyl radical, was found to be 28-fold more potent than (+)-catechin.