1610022-28-0

Basic information

• Product Name: 1-((2R,4S,5R)-4-hydroxy-3-methylene-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• Synonyms: 1-((2R,4S,5R)-4-hydroxy-3-methylene-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 1610022-28-0
• Molecular Weight: 396.559
• Mol File: 1610022-28-0.mol

Chemical Properties

• CAS DataBase Reference: 1-((2R,4S,5R)-4-hydroxy-3-methylene-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((2R,4S,5R)-4-hydroxy-3-methylene-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(1610022-28-0)
• EPA Substance Registry System: 1-((2R,4S,5R)-4-hydroxy-3-methylene-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(1610022-28-0)

Safety Data

• Hazardous Substances Data: 1610022-28-0(Hazardous Substances Data)

Upstream product

• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 119410-95-6 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylenetetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 1610022-30-4 (2R,3S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methylene-2-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-3-yl ((perfluorobenzoyl)oxy)carbamate 

Relevant articles and documents

Novel intramolecular aminohydroxylation toward the syntheses of 2′-amino-2′-ethynyl nucleosides

Syntheses of both 2′-amino-2′-ethynyl guanosine and uridine, using an intramolecular aminohydroxylation reaction as the key step, are described. The corresponding 5′-O-triphosphates of the aforementioned nucleosides were obtained and the inhibitory activity was subsequently evaluated against the hepatitis C virus NS5B polymerase.

2 -ALKYNYL SUBSTITUTED NUCLEOSIDE DERIVATIVES FOR TREATING VIRAL DISEASES

The present invention relates to 2'-Alkynyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to compositions comprising at least one 2'-Alkynyl Substituted Nucleoside Derivative, and methods of using the 2'-Alkynyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.