119410-95-6

Basic information

• Product Name: 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylene-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• Synonyms: 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylene-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 119410-95-6
• Molecular Formula: C₁₀H₁₂N₂O₅
• Molecular Weight: 240
• Mol File: 119410-95-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 173.5 °C (decomp)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• PKA: 9.29±0.10(Predicted)
• CAS DataBase Reference: 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylene-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylene-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(119410-95-6)
• EPA Substance Registry System: 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylene-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(119410-95-6)

Safety Data

• Hazardous Substances Data: 119410-95-6(Hazardous Substances Data)

Usage

Uses

2''-Deoxy-2''-methyleneuridine is an analog of Uridine (U829910) and has antiherpesvirus, antitumor, antiviral, and anticancer activity.

Upstream product

• 79-37-8 oxalyl dichloride 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 58-96-8 uridine 
• 114262-49-6 1-(2'-C-methyl-β-D-arabinofuranosyl)uracil 
• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 84828-97-7 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione 
• 146952-83-2 3',5'-di-O-acetyl-2'-deoxy-2'-methylene-β-D-uridine 
• 134660-24-5 1-((2R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-2-yl)pyrimidine-2,4 (1H,3H)-dione 
• 102789-14-0 1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyl-9-methylenetetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 148943-50-4 1-(5-O-(tert-Butyldiphenylsilyl)-2-deoxy-2-methylene-β-D-erythro-pentofuranosyl)uracil 
• 1610022-30-4 (2R,3S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methylene-2-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-3-yl ((perfluorobenzoyl)oxy)carbamate 
• 1610022-28-0 1-((2R,4S,5R)-4-hydroxy-3-methylene-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 1496551-72-4 1-((2R,3R,4R,5R)-3-chloro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 1496551-77-9 MK-3682 
• 146952-85-4 O²,3'-anhydro-2'-deoxy-2'-methylidene-5'-O-trityluridine 
• 142688-37-7 Methanesulfonic acid (2R,3S,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-methylene-2-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 142688-39-9 (3'R)-2'-deoxy-2'-methylidene-5'-O-trityluridine 
• 142688-44-6 (3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-tritylcytidine 
• 142688-43-5 (3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-trityluridine 
• 142688-38-8 (3'R)-3'-O-benzoyl-2'-deoxy-2'-methylidene-5'-O-trityluridine 
• 142688-42-4 2',3'-didehydro-2',3'-dideoxy-2'-phenylselenomethyl-5'-O-trityluridine 
• 142688-41-3 2',3'-didehydro-2',3'-dideoxy-2'-phenylthiomethyl-5'-O-trityluridine 
• 142688-40-2 2'-azidomethyl-2',3'-didehydro-2',3'-dideoxy-5'-O-trityluridine 

Relevant articles and documents

Novel intramolecular aminohydroxylation toward the syntheses of 2′-amino-2′-ethynyl nucleosides

Syntheses of both 2′-amino-2′-ethynyl guanosine and uridine, using an intramolecular aminohydroxylation reaction as the key step, are described. The corresponding 5′-O-triphosphates of the aforementioned nucleosides were obtained and the inhibitory activity was subsequently evaluated against the hepatitis C virus NS5B polymerase.

Novel 2'-fluorouracil nucleoside and synthetic method

The invention discloses a novel 2'-fluorouracil nucleoside and a synthetic method. A structural general formula of a compound is shown as the specification, and the synthetic method comprises the following steps in the specification. The synthesis method

PROCESS FOR MAKING CHLORO-SUBSTITUTED NUCLEOSIDE PHOSPHORAMIDATE COMPOUNDS

The present invention is directed to a process for making Chloro-Substituted Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).