1610027-03-6Relevant articles and documents
An efficient synthesis strategy to the core structure of 6-5-6-5-6-membered epipolythiodiketopiperazines
Zipfel, Hannes F.,Carreira, Erick M.
, p. 2854 - 2857 (2014)
A concise route to the core structure 1 of 6-5-6-5-6-membered epipolythiodiketopiperazines is described. The strategy relies on construction of the pyrrolines by double nucleophilic opening of a bis(oxabicyclo[2.2.1] heptene) 2, obtained after bidirectional condensation of N,N′- diacetyldiketopiperazine (4) with aldehyde 3.