161003-27-6

Basic information

• Product Name: Phosphoric acid (R)-2,3-bis-hexadecyloxy-propyl ester 4-(diphenoxy-phosphoryloxy)-cyclohexyl ester phenyl ester
• Synonyms: Phosphoric acid (R)-2,3-bis-hexadecyloxy-propyl ester 4-(diphenoxy-phosphoryloxy)-cyclohexyl ester phenyl ester
• CAS NO: 161003-27-6
• Molecular Weight: 1027.35
• Mol File: 161003-27-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phosphoric acid (R)-2,3-bis-hexadecyloxy-propyl ester 4-(diphenoxy-phosphoryloxy)-cyclohexyl ester phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphoric acid (R)-2,3-bis-hexadecyloxy-propyl ester 4-(diphenoxy-phosphoryloxy)-cyclohexyl ester phenyl ester(161003-27-6)
• EPA Substance Registry System: Phosphoric acid (R)-2,3-bis-hexadecyloxy-propyl ester 4-(diphenoxy-phosphoryloxy)-cyclohexyl ester phenyl ester(161003-27-6)

Safety Data

• Hazardous Substances Data: 161003-27-6(Hazardous Substances Data)

Upstream product

• 67337-03-5 (2R)-3-hydroxy-1,2-di-hexadecyloxypropane 
• 13071-57-3 (R)-((2,3-bis(hexadecyloxy)propoxy)methyl)benzene 
• 112-82-3 hexadecanyl bromide 

Relevant articles and documents

Inhibition of human erythrocyte membrane phosphatidylinositol 4-kinase by phospholipid analogues

Analogues of phosphatidylinositol (PtdIns, 1) have been synthesized to investigate the structural requirements for inhibition of a PtdIns 4-kinase obtained from human erythrocyte membranes. While the presence of either D-1 or D-3 stereochemistry in the inositol moiety greatly influences the degree of inhibition produced by PtdIns analogues, the stereochemistry of the glycerol moiety is of little consequence. Neither structural feature however, makes a significant contribution to binding affinity. Competitive inhibitory activity was found to be retained (or even enhanced) in substantially simpler analogues consisting of 1 or 2 hydrocarbon chains attached to a charged phosphate head group, such as in the phosphatidic acids, 24 and 26. The observation that the phosphatidylinositol 4-phosphate (PtdIns 4P) and phosphatidic acid analogues (eg, 16 or 17, and 26 respectively) inhibit PtdIns 4-kinase may suggest that such species have a regulatory role in PtdIns turnover.