161003-29-8Relevant academic research and scientific papers
Synthesis of derivatives of muramic acid and C-1 homologated α-D-glucose as potential inhibitors of bacterial transglycosylase
Brooks, Gerald,Edwards, Peter D.,Hatto, Julia D. I.,Smale, Terence C.,Southgate, Robert
, p. 7999 - 8014 (1995)
Phosphate derivatives of muramic acid, incorporating a lipid-like group, have been synthesised as potential inhibitors of bacterial transglycosylase. The Lewis acid catalysed addition of unsaturated alkyl silanes to methyl α- D-glucopyranoside, followed by an oxidative cleavage, has been used to provide a route to C-1 homologues of glucose. Conversion of α-D-glucose methanephosphonic acid to esters derived from lipid-like groups is also described.
