161005-39-6Relevant articles and documents
Pyrazine alkaloids via dimerization of amino acid-derived α-amino aldehydes: Biomimetic synthesis of 2,5-diisopropylpyrazine, 2,5-bis(3- indolylmethyl)pyrazine and actinopolymorphol C
Badrinarayanan, Sandhya,Sperry, Jonathan
supporting information; scheme or table, p. 2126 - 2132 (2012/04/23)
The dimerization of amino acid-derived α-amino aldehydes provides a short, biomimetic synthesis of several 2,5-disubstituted pyrazine natural products. The α-amino aldehyde intermediates were generated in situ by the hydrogenolysis of their Cbz-derivative
Synthesis of substituted pyrrolin-4-ones from amino acids in mild conditions via a gold-catalyzed approach
Gouault, Nicolas,Le Roch, Myriam,Cornee, Carole,David, Michele,Uriac, Philippe
scheme or table, p. 5614 - 5617 (2009/12/08)
(Chemical Equation Presented) The gold-catalyzed cyclization of various α-amino-ynone derivatives gave the corresponding pyrrolin-4-ones in high yields. Moreover, the use of gold(III) oxide as catalyst allows a moderate to total stereocontrol during the cyclization. These pyrrolin-4-ones are highly useful intermediates for the synthesis of functionalized pyrrolidines and other natural products.
