161016-69-9Relevant academic research and scientific papers
Reactions of 2′,3′-Di-O-mesyl-lyxo-uridine with secondary amines: First report on the one-pot conversion of mesylated nucleosides to enaminonucleosides and the crystal structure of α-enamine
Sakthivel, Kandasamy,Pathak, Tanmaya,Suresh, Cheravakkattu G.
, p. 13251 - 13260 (1994)
2′,3′-Di-O-mesyl-5′-O-trityl-lyxo-uridine 1 reacted with secondary amines to produce enaminonucleosides 2a-d and 3a-d. Intermediacy of 2′-ketouridine was essential for the anomerisation and enamine formation to take place. The structure of the β-enamine was established unambiguously by analysing the hydrolysed product and that of α-enamine was proved with the help of crystal structure analysis.
Opening of 2',3'-O-anhydro-ring of 2',3'-O-anhydro-lyxo-uridine by alkyl- and arylamines. Easy syntheses and preparative uses of 2'-deoxy-2'-alkylamino-xylo- and 3'-deoxy-3'-alkylamino-ara-uridines
Bera,Pathak,Langley
, p. 1459 - 1470 (2007/10/02)
Contrary to the previous report, under controlled conditions alkylamines, both primary and secondary and arylamines, opened the epoxide ring of 1-(5-O-trityl-2,3-O-anhydro-β-D-lyxo-furanosyl)-uracil to produce 2'-deoxy-2'-alkylamino-xylo- and 3'-deoxy-3'-
