161016-70-2

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 161016-69-9 5'-O-trityl-3'-deoxy-3'-N-morpholino-ara-uridine 
• 96253-10-0 1-[2,3-epoxy-5-O-(triphenylmethyl)-β-D-lyxofuranosyl]pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 252258-07-4 1-((1R,3S,3aR,8aR)-3-Trityloxymethyl-octahydro-2,6,8-trioxa-3b-aza-cyclopenta[a]inden-1-yl)-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Thermal degradation of sugar-modified uridine N-oxides: Olefination, oxazolidination and rearrangements

The degradation pattern of the N-oxides of various tertiary aminouridines is established. The N-oxide of 3'-deoxy-3'-morpholino- arauridine generated double bonds in the carbohydrate moiety without much selectivity, whereas epimino uridine N-oxides genera

Reactions of 2′,3′-Di-O-mesyl-lyxo-uridine with secondary amines: First report on the one-pot conversion of mesylated nucleosides to enaminonucleosides and the crystal structure of α-enamine

2′,3′-Di-O-mesyl-5′-O-trityl-lyxo-uridine 1 reacted with secondary amines to produce enaminonucleosides 2a-d and 3a-d. Intermediacy of 2′-ketouridine was essential for the anomerisation and enamine formation to take place. The structure of the β-enamine was established unambiguously by analysing the hydrolysed product and that of α-enamine was proved with the help of crystal structure analysis.