1610355-13-9

Basic information

• Product Name: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonine [phenylmethyl hydrogen Phosphate (ester)]phenylmethyl ester
• Synonyms: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonine [phenylmethyl hydrogen Phosphate (ester)]phenylmethyl ester
• CAS NO: 1610355-13-9
• Molecular Weight: 601.593
• Mol File: 1610355-13-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonine [phenylmethyl hydrogen Phosphate (ester)]phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonine [phenylmethyl hydrogen Phosphate (ester)]phenylmethyl ester(1610355-13-9)
• EPA Substance Registry System: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonine [phenylmethyl hydrogen Phosphate (ester)]phenylmethyl ester(1610355-13-9)

Safety Data

• Hazardous Substances Data: 1610355-13-9(Hazardous Substances Data)

Upstream product

• 175291-56-2 Fmoc-L-Thr(HPO₃Bzl)-OH 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1629149-57-0 benzyl O-[(benzyloxy){[(2,2-dimethylpropanoyl)oxy]methoxy}phosphoryl]-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-threoninate 

Relevant articles and documents

Design and synthesis of Fmoc-Thr[PO(OH)(OPOM)] for the preparation of peptide prodrugs containing phosphothreonine in fully protected form

The design and efficient synthesis of N-Fmoc-phosphothreonine protected by a mono-(pivaloyloxy)methyl (POM) moiety at its phosphoryl group (Fmoc-Thr[PO(OH)(OPOM)]-OH, 1, is reported. This reagent is suitable for solid-phase syntheses employing acid-labile resins and Fmoc-based protocols. It allows the preparation of phosphothreonine (pThr)-containing peptides bearing bis-POM-phosphoryl protection. The methodology allows the first reported synthesis of pThr-containing polypeptides having bioreversible prodrug protection, and as such it should be useful in a variety of biological applications.